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GPU Accelerated Cryo-Electron Microscopy
RELION (REgularised LIkelihood OptimisatioN) is an image processing software designed specifically for cryo-electron microscopy (cryo-EM). Developed by the group of Sjors Scheres at the MRC Laboratory of Molecular Biology, the Relion framework is revolutionizing the cryo-EM field. It is a stand-alone computer program built for the refinement of macromolecular structures by single-particle analysis of electron cryo-microscopy data. Relion employs an empirical Bayesian approach for refinement of multiple 3D reconstructions or 2D class averages. With alternative approaches often relying on user expertise for the tuning of parameters, Relion can find an optimal way of filtering the data automatically.
Exxact Relion GPU Systems
All Exxact Relion systems come preinstalled with the latest version and updates. Our Relion Software Suite includes: CentOS 7, Relion 2, Motioncorr, MotionCor2, Gctf, CTFFind4, Chimera, Summovie, Unblur, ResMap, and more.
Each system is fully turnkey and are ready to run out of the box for generating guaranteed performance. Here are some of our most popular models:
Relion Optimized
Entry-Level Workstation
- 1x Intel Core i7-7820X
- 4x NVIDIA GTX 1080 Ti
- 8x 16GB Memory
- 1x 256GB SSD (OS) / 2x 2TB SSD
- Relion Software
- 3 Year Warranty
Relion Optimized
Mid-Level Workstation- 2x Intel Xeon Scalable Family (Silver)
- 4x NVIDIA GTX 1080 Ti
- 12x 16GB Memory
- 2x 240GB SSD (OS) / 2x 2TB HDD
- Relion Software
- 3 Year Warranty
Relion Optimized
High-Level Server
- 2x Intel Xeon Scalable Family (Gold)
- Up to 8x NVIDIA Tesla GPU's
- 12x 32GB Memory
- 1x 512GB M.2 SSD (OS) / 2x 2TB HDD
- Relion Software
- 3 Year Warranty
GPU Accelerated Cryo-EM Pipeline
With Exxact Relion GPU Systems, users can address the most computationally intensive steps of the cryo-EM structure determination workflow. Processes such as image classification and high-resolution refinement can achieve a dramatic speed up in computing time by using one of our systems.
Relion Iteration GPU vs CPU Comparison
With GPU-acceleration introduced to RELION 2.0, the cryo-EM process has become expedited significantly. Massive speed-up improvements in the classification steps can be seen when comparing a 4x GPU workstation and a 280x CPU core cluster.
Source: Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2 Kimanius et al. 2016
- Rack Height: 2U
- Processor Supported: 2x Intel E5-2600 v3/v4
- Drive Bays: 8x 3.5" Hot-Swap
- Supports up to 4x Double-Wide cards
- Rack Height: 2U
- Processor Supported: 2x Intel Xeon Scalable Family
- Drive Bays: 8x 3.5" Hot-Swap (2x NVMe)
- Supports up to 4x Double-Wide cards
- Rack Height: 4U
- Processor Supported: 2x Intel Scalable Family
- Drive Bays: 14x 2.5" Hot-Swap
- Supports up to 8x Double-Wide cards
- Rack Height: 4U
- Processor: 1x Intel Core X-Series
- Drive Bays: 8x 3.5" Hot-Swap
- Supports up to 4x Double-Wide cards
- Form Factor: 4U Rackmountable / Tower
- Processor: 2x Intel Xeon Scalable family
- Drive Bays: 4x 3.5"/2.5" Hot-Swap
- Up to 5x Double-Wide cards
- Rack Height: 4U
- Processor: 2x Intel Xeon Scalable family
- Drive Bays: 14x 2.5" Hot-Swap
- Up to 10x Double-Wide cards
- Rack Height: 4U
- Processor: 1x Intel Core i7, E5-1600 v3/v4, E5-2600 v3/v4
- Drive Bays: 8x 3.5" Hot-Swap
- Supports up to 4x Double-Wide cards
- Rack Height: 4U
- Processor Supported: 2x Intel E5-2600 v3/v4
- Drive Bays: 24x 2.5" Hot-Swap
- Supports up to 8x Double-Wide cards
- Rack Height: 4U
- Processor Supported: 2x Intel E5-2600 v3/v4
- Drive Bays: 24x 2.5" Hot-Swap
- Supports up to 10x Double-Wide cards in a Single Root Complex
- Rack Height: 4U
- Processor Supported: 2x Intel E5-2600 v3/v4
- Drive Bays: 8x 3.5" Hot-Swap
- Supports up to 4x Double-Wide GPUs
- Rack Height: 4U
- Processor Supported: 2x Intel Xeon Scalable Family
- Drive Bays: 8x 3.5" Hot-Swap
- Supports up to 4x Double-Wide GPUs
- Rack Height: 4U
- Processor Supported: 2x Intel Xeon Scalable Family
- Drive Bays: 24x 2.5" Hot-Swap
- Supports up to 8x Double-Wide cards
- Rack Height: 4U
- Processor Supported: 2x Intel Xeon Scalable Family
- Drive Bays: 24x 2.5" Hot-Swap
- Supports up to 10x Double-Wide cards in a Single-Root complex
- Form Factor: 4U Rackmountable / Tower
- Processor: 1x Intel Core X-Series
- Drive Bays: 8x 3.5" Hot-Swap
- Supports up to 4x Double-Wide cards
- Form Factor: 4U Rackmountable / Tower
- Processor: 2x Intel Xeon Scalable family
- Drive Bays: 4x 3.5"/2.5" Hot-Swap
- Up to 5x Double-Wide cards